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羟基喜树碱联合草酸铂、亚叶酸钙和5-氟尿嘧啶治疗晚期大肠癌的临床观察
对照组22例仅采用常规治疗，比较治疗前、治疗2、24h后两组同期动脉血气及呼吸频率、心率改变。结果治疗组PaO：、PaCO、pH值较治疗前明显改善(P<0．05),[link widoczny dla zalogowanych]，与对照组比较差异有统计学意义(P<0．05)；呼吸频率、心率改变也较对照组明显(P<0．05)。气管插管发生率及平均住院天数均少于对照组(P<0．05),[link widoczny dla zalogowanych]。结论BiPAP是治疗慢性阻塞性肺疾病急性发作期并Ⅱ型呼吸衰竭经济、有效的方法。【关键词】慢性阻塞性肺疾病；呼吸衰竭；无创正压通气Treatmentofrespiratoryfailuresecondarytotheacuteexacerbationofchronicobstructivepulmonarydiseasesthroughbilevelpositiveairwaypressureventilationvianasal／mouthmaskHEMing，WUShengling．DepartmentofMedicine，XinhaiHospitalofGuangzhou，Guangzhou510300，Guangdong【Abstract】ObjectiveToevaluatetheclinicaleffectivenessbyusingbilevelpositiveairwaypressure(BiPAP)ventilationviana-salfmouthmaskinpatientswithrespiratoryfailuresecondarytotheacuteexacerbationofchronicobstructivepulmonarydiseases(COPD)．Methods23patientswererandomlydividedintostandardtherapyplusBiPAPand22pafien~tostandardtherapy．Cliniaclmani~smtion(includingrespiratoryrate，heartrate，bloodpressureandconsciousstatus)andarterialbloodgasanalysisbeforeandafter2h，24haftertreatmentineachgroupwerecomparativelyanalyzed．ResultsAftertreatmentbyBiPAP，patientsshowedasignificantimprovementinPaOz,[link widoczny dla zalogowanych]，PaCO2，andclinicalmanifestation．Andtherewasasignificantdifferencebetweentwogroups(P<0．05)．Con-clusionBiPAPventilationiseffectiveinpatientswithrespiratoryfailureduringacuteexacerbationofCOPD．【Keywords】Chronicobstructivepulmonary；Respiratoryfailure；Noinvasivepositivepressureventilation随着近年来无创通气在临床中的广泛应用，为抢救呼吸衰Ⅱ型呼吸衰竭中的疗效及临床应用价值,[link widoczny dla zalogowanych]。竭患者提供了新的手段,[link widoczny dla zalogowanych]。本文旨在深讨经El／鼻面罩双水平气1对象与方法道正压通气(BiPAP)在慢性阻塞性肺疾病(COPD)急性发作期1．1研究对象：2003年6月茎2006年10月在我院就诊的45
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