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人多药耐药基因—1及二氢叶酸还原酶基因共转导小鼠造？…
lood,[link widoczny dla zalogowanych]，1994；84：1408—1414CotransductionofHumanmdr·1andDihydrofolateReductaseGenesintoMurineHematopoieticCellsLIUXiaodanYUXiaodanGUoZikuanLIXiusenLIUYuanlinMAONing(InstituteofBasicMedicalSciencesB~ing100850)AbstractTransferofdrugresistancegeneslntohematopoieticcellsiSanattractiveapproachtoprotecthematopoieticsystemfromthetoxiceffectsbychemotherapeuticagentsincancerpatientsInthisstudy,[link widoczny dla zalogowanych]，transductionofmdr一1incombinationwithdihydrofolatereductase(dhfr)genewasperformed，andtheexpressionofexogenousgenesandchemoprotectioncapacityinmousebonemarrowcellswereobservedTheresultsshowedthatapproximately15％ofbone1T~rlx3Wcellstransfectedwiththeretroviralvectorexpressedmdr1asassayedbyflowcytomelry．Genetramsferresultedinabout09—13foldand0．5—26foldincreaseintheresistanceofCFU_GMtotaxolandmethotrexateinvitro，respectively(P<005)Moreover．sevenmonthsaftertransplantationtosyngeneicmicewithmdr-1anddhfr-transfeetedbonemarrowcells．peripheraibloodcellsinrecipientswerestillpositivef0rgpl70asevaluatedbyFAcsaswellasformdr一1anddhfrbyPcRamplification．Theseresultsindicatethathematopoieticprogenitorscanbetransfectedbyretroviruscontainingmdr一1anddhfrgenes,[link widoczny dla zalogowanych]，andthatfunctionaldrugresistanceaccompaniestheirexpressions．Furthermore，geneticchimerlsmmightexistinhematopoieticstemcells．Inconclusion,[link widoczny dla zalogowanych]，transferandexpressionofmdr一1anddhfrgenesinbonemarrowcellsmightbeappli—cableingenetherapyresearchincancerpatients．Keywordsdrugresistancegenemultidrugresistancegene一1dihydrofolatereductasegenegenecotransductionhematopoieticcells
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