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Xi Libin amine anti-tuberculosis drugs to prevent liver damage caused by clinical observation

[Paper Keywords] Xi Libin amine; prevention; tuberculosis; drug induced liver
[Abstract] Objective: To investigate the Xili Bin amine untreated sputum positive pulmonary tuberculosis on anti-tuberculosis drugs induced liver damage in patients with preventive effect. Methods: 242 patients with previously untreated sputum positive pulmonary tuberculosis were divided into study group and control group, all applications \Results: The incidence of drug induced liver group 6.6%, 4.1% interrupt anti-TB chemotherapy, chemotherapy adjusted rate was 1.6%; with the control group, 19.2%, 14.2% and 9.2% compared with significant difference (P TB patients receiving anti-tuberculosis drugs induced liver injury can occur during chemotherapy, can cause some patients then have to half-way stop, the impact of regular chemotherapy. Can effectively reduce or avoid chemotherapy and to be the occurrence of liver damage,UGG ブーツ, in recent years,nike air max, we untreated sputum positive pulmonary tuberculosis patients in the anti-TB drugs at the same time, I Xili Bin amine or Glucurolactone the same clothes to the prevention of drug induced liver injury and its effects were compared. Are reported as follows: 1 objects and methods 1.1 object 2001 年 1 month to December 2003 I have treated 242 cases of tuberculosis hospital patients, 167 cases of male and female 75 cases; aged 18 to 72 years; patients with the following conditions: ① the initial treatment of tuberculosis, clinical manifestations are fever, fatigue, night sweats, weight loss and other common symptoms of TB, X-ray film showed pulmonary infiltration of tuberculosis, sputum smear Check TB positive; ② sputum culture confirmed Mycobacterium tuberculosis to isoniazid (H), rifampicin (R), streptomycin (S),moncler jacken, ethambutol (E) and pyrazinamide (Z)-sensitive; ③ None of these drugs and the general history of antibiotic allergy; ④ no mental, neurological history; ⑤ no immune deficiency disease or history of immunosuppressive agents; ⑥ non-pregnant and lactating women; ⑦ mood, liver, kidney dysfunction and diabetes; ⑧ not alcohol use and nearly 3 weeks without fever, tranquilizers and other drugs that affect liver function; ⑨ patients agreed to treatment. Type of tuberculosis by 1998 standards [1], Ⅲ type 215 cases, Ⅲ + Ⅳ type in 27 cases. 242 cases were randomly divided into two groups; study group of 122 cases, male 84 cases, 38 female, aged 18 to 72 years, mean 37.2 years; the control group of 120 patients,ghd stijltang, 83 males and 37 females, aged 19 70 years old, average 63.6 years old. Two middle-aged, serious condition, and the proportion of patients associated with underlying diseases are similar and comparable. 1.2 Methods chemotherapy: two groups were selected 2HRZS (E) / 4HR chemotherapy: H 300 mg, 1 times / d; R 450 mg, 1 times / d; Z 750 mg, 2 times / d ; S 750 mg1 times / d, or E 750 mg, 1 times / d, intramuscular injection. Observation group while taking Xili Bin amine (Yantai only the production of Chu Pharmaceutical Co., Ltd.) 50 ~ 100 mg, 3 times / d; the control group while taking Glucurolactone 200 mg, 3 times / d. Liver damage liver function tests to determine: the patients were in the check liver function before chemotherapy 2, to exclude primary liver disease and hepatitis B virus carriers; the strengthening of every 1 to 2 weeks to check 1; consolidation of the monthly check 1; chemotherapy such as nausea, vomiting, anorexia, abdominal distension and other symptoms, any review of liver function. To alanine aminotransferase (ALT)> 30 U / L as liver damage. 1.3 interrupt and re-adjustment of the standard anti-TB chemotherapy, standard chemotherapy regimens to ALT ≥ 90 U / L, and liver by short-term intensive treatment (treatment used to strengthen liver Ganlixin, inosine, vitamin C and other intravenous medicine, but the observation group continued to take Xili Bin amine) is still progressively increased after the ALT as interrupt the standard anti-TB chemotherapy; to apply the anti-tuberculosis drugs after severe liver dysfunction, and abnormal liver function to disable anti-TB drugs because of the parallel protection various indicators of normal liver after treatment, and to restore the original shortly after chemotherapy and abnormal liver function as a re-adjustment of the standard chemotherapy regimen.
2 results 2.1 compared to liver damage liver damage in the two groups occurred in the 1 to 8 weeks after chemotherapy,ugg boots reduziert, including the observation group, 8 patients (6.6%), elevated aminotransferases, elevated in the range of 56 ~ 228 U; control group, 23 patients (19.2%), increased the range of 88 ~ 336 U. The two groups, the incidence of liver damage were significantly different (χ2 = 8.61, P <0.01). 2.2 chemotherapy regimens interrupted or re-adjustment of the comparison group interrupt chemotherapy observed in 5 patients (4.1%) in the control group were interrupted chemotherapy, 17 (14.2%), the two groups, the rate of interruption of chemotherapy Statistics School difference (χ2 = 7.42, P <0.01); the observation group were last adjusted chemotherapy, 2 patients (1.6%), chemotherapy in the control group were last adjusted in 11 patients (9.2%), the two groups, the final adjustment of chemotherapy rates were significantly different (χ2 = 6.74, P <0.01). 2.3 drug induced liver damage

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